Enzyme Inhibition: Competitive, Non-Competitive, and Allosteric Regulation
Students will investigate passive transport mechanisms, including diffusion and osmosis, and their importance in maintaining cellular homeostasis.
Key Questions
- Distinguish between competitive, non-competitive, and irreversible inhibition at the molecular level, predicting the effect of each inhibition type on the Michaelis-Menten curve and explaining the change in Km and Vmax values observed.
- Analyse how allosteric inhibition and feedback inhibition enable cells to regulate the flux through metabolic pathways in response to changing concentrations of substrates, products, and signalling molecules.
- Evaluate the therapeutic rationale for designing competitive inhibitors as drugs — using statins as an example — including the implications of dose-response relationships, reversibility, and the potential for drug resistance through target mutation.
MOE Syllabus Outcomes
Suggested Methodologies
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