Bulk Transport: Endocytosis, Exocytosis, and the Endomembrane System
Students will be introduced to the overall process of cellular respiration, understanding how organisms break down glucose to release energy.
Key Questions
- Compare phagocytosis, pinocytosis, and receptor-mediated endocytosis in terms of mechanism, cargo specificity, and cellular role, using examples from macrophage function and LDL cholesterol uptake.
- Explain how the secretory pathway — from ribosome-bound ER through Golgi apparatus to secretory vesicles — ensures the correct post-translational modification, targeting, and release of proteins via exocytosis.
- Evaluate how familial hypercholesterolaemia — caused by mutations in the LDL receptor — demonstrates the physiological consequences of defective receptor-mediated endocytosis, and explain why LDL accumulates in the blood.
MOE Syllabus Outcomes
Suggested Methodologies
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