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Browse by Grade: 12th Grade

United States · Common Core State Standards

12th Grade Biology

An intensive exploration of the mechanisms of life from molecular interactions to ecosystem dynamics. Students analyze complex biological systems using evidence based inquiry to understand how life sustains itself and evolves in a changing world.

4 units·50 topics·Ages 17-18

01The Molecular Basis of Life

13 topics·Weeks 1-9

Investigation into the chemical foundations of biological systems and the specialized functions of cellular organelles.

Water: The Solvent of Life

Examine the unique properties of water and its critical role in biological processes and cellular function.

Concept MappingInquiry Circle
Carbon Chemistry and Organic Molecules

Explore the versatility of carbon as the backbone of organic molecules and its role in forming diverse biological compounds.

Stations RotationConcept Mapping
Carbohydrates and Lipids: Structure & Function

Analyze the structures and diverse functions of carbohydrates and lipids in energy storage, structural support, and signaling.

JigsawCase Study Analysis
Proteins: The Workhorses of the Cell

Investigate the complex structures of proteins and their myriad roles as enzymes, transporters, and structural components.

Inquiry Circle
Nucleic Acids: Information Storage

Examine the structure and function of DNA and RNA as the carriers of genetic information and their roles in gene expression.

Stations RotationConcept Mapping
Enzymes and Metabolic Pathways

Study the role of enzymes as biological catalysts and their regulation within metabolic pathways.

Simulation GameCase Study Analysis
Cell Structure and Organelle Function

Investigate the specialized structures and functions of eukaryotic and prokaryotic cell organelles.

Gallery WalkConcept Mapping
Photosynthesis: Capturing Light Energy

Examine the light-dependent and light-independent reactions of photosynthesis and their importance for life on Earth.

JigsawSimulation Game
Cellular Respiration: Releasing Chemical Energy

Study the stages of cellular respiration (glycolysis, Krebs cycle, electron transport chain) and ATP production.

Case Study AnalysisCollaborative Problem-Solving
Membrane Structure and Selective Permeability

Investigate the fluid mosaic model of the cell membrane and its role in regulating substance passage.

Simulation GameConcept Mapping
Passive and Active Transport

Compare and contrast passive transport (diffusion, osmosis, facilitated diffusion) and active transport mechanisms.

Simulation GameProblem-Based Learning
Cell Communication and Signal Transduction

Study how cells receive, process, and respond to external signals through signal transduction pathways.

Case Study AnalysisJigsaw
Cell Cycle and Mitosis

Examine the stages of the cell cycle and the process of mitosis for growth and repair.

Stations RotationConcept Mapping

02Information Storage and Transfer

13 topics·Weeks 10-18

Focus on the mechanisms of heredity, gene expression, and the ethical implications of genetic engineering.

DNA Replication: Copying the Blueprint

Investigate the semi-conservative nature of DNA replication and the enzymes involved.

Simulation GameStations Rotation
Transcription: From DNA to RNA

Explore the process of transcription, where genetic information from DNA is copied into RNA.

Concept MappingJigsaw
Translation: From RNA to Protein

Study the process of translation, where mRNA is used to synthesize proteins at the ribosome.

Stations RotationSimulation Game
Gene Regulation and Epigenetics

Investigate mechanisms of gene regulation in prokaryotes and eukaryotes, including epigenetic modifications.

Case Study AnalysisInquiry Circle
Meiosis and Genetic Variation

Examine the process of meiosis and how it generates genetic diversity in sexually reproducing organisms.

Stations RotationConcept Mapping
Mendelian Genetics: Basic Principles

Apply Mendel's laws of inheritance to predict patterns of trait transmission.

Problem-Based LearningCollaborative Problem-Solving
Non-Mendelian Inheritance

Investigate complex inheritance patterns such as incomplete dominance, codominance, and polygenic traits.

Case Study AnalysisJigsaw
Pedigree Analysis and Human Genetic Disorders

Use pedigree charts to track genetic traits and disorders through human generations.

Case Study AnalysisProblem-Based Learning
Genetic Engineering Techniques

Explore the tools and techniques used to manipulate DNA, including recombinant DNA technology and PCR.

Simulation GameProject-Based Learning
CRISPR and Gene Editing

Investigate the CRISPR-Cas9 system and its applications in gene editing, along with associated ethical considerations.

Socratic SeminarFormal Debate
Genomics and Proteomics

Study the fields of genomics and proteomics, focusing on large-scale analysis of genes and proteins.

Case Study AnalysisInquiry Circle
Forensic Genetics and DNA Profiling

Examine the applications of DNA profiling in forensic science, paternity testing, and conservation.

Document MysteryCase Study Analysis
Bioethics of Genetic Technologies

Discuss the societal and ethical implications of genetic technologies, including privacy and access.

Socratic SeminarPhilosophical Chairs

03Evolutionary Dynamics

13 topics·Weeks 19-27

Analyzing the evidence for evolution and the mechanisms that drive the diversification of life on Earth.

Darwin and the Theory of Natural Selection

Explore the historical context of Darwin's theory and the core principles of natural selection.

Case Study AnalysisJigsaw
Mechanisms of Evolution: Mutation and Gene Flow

Investigate mutation and gene flow as sources of genetic variation and evolutionary change.

Inquiry CircleSimulation Game
Genetic Drift and Non-Random Mating

Study genetic drift (bottleneck and founder effects) and non-random mating as evolutionary forces.

Collaborative Problem-SolvingCase Study Analysis
Adaptation and Fitness

Examine how organisms adapt to their environments and the concept of evolutionary fitness.

Simulation GameCase Study Analysis
Speciation: The Origin of New Species

Investigate the mechanisms of speciation, including allopatric and sympatric speciation.

JigsawConcept Mapping
Fossil Evidence and Geologic Time

Analyze fossil records and radiometric dating to understand Earth's history and evolutionary changes.

Stations RotationTimeline Challenge
Comparative Anatomy and Embryology

Examine homologous and analogous structures and developmental similarities as evidence for common ancestry.

Gallery WalkCase Study Analysis
Molecular Evidence for Evolution

Study molecular clocks, DNA, and protein sequence comparisons to infer evolutionary relationships.

Inquiry CircleConcept Mapping
Phylogenetic Trees and Cladograms

Interpret and construct phylogenetic trees and cladograms to represent evolutionary relationships.

Stations RotationHexagonal Thinking
Hardy-Weinberg Equilibrium

Apply the Hardy-Weinberg principle to calculate allele and genotype frequencies in populations.

Collaborative Problem-SolvingProblem-Based Learning
Factors Disrupting Genetic Equilibrium

Investigate how natural selection, genetic drift, gene flow, mutation, and non-random mating disrupt Hardy-Weinberg equilibrium.

Inquiry CircleCase Study Analysis
Patterns of Evolution

Examine different patterns of evolution, including convergent evolution, divergent evolution, and coevolution.

Gallery WalkConcept Mapping
Mass Extinctions and Adaptive Radiations

Study the causes and consequences of mass extinctions and subsequent adaptive radiations.

Case Study AnalysisSocratic Seminar

04Ecological Interactions

11 topics·Weeks 28-36

Exploring the complex relationships between organisms and their environments across different scales.

Ecosystem Components and Energy Flow

Identify biotic and abiotic components of ecosystems and trace energy flow through trophic levels.

Concept MappingJigsaw
Biogeochemical Cycles: Carbon and Nitrogen

Investigate the cycling of carbon and nitrogen through living organisms and the environment.

Project-Based LearningInquiry Circle
Biogeochemical Cycles: Water and Phosphorus

Study the water and phosphorus cycles and their importance for ecosystem health.

Concept MappingCase Study Analysis
Population Growth Models

Model population growth using exponential and logistic growth curves and analyze limiting factors.

Simulation GameCollaborative Problem-Solving
Density-Dependent and Density-Independent Factors

Differentiate between density-dependent and density-independent limiting factors affecting population size.

Case Study AnalysisDecision Matrix
Human Population Dynamics

Examine human population growth patterns, demographic transitions, and their environmental impacts.

World CaféFormal Debate
Interspecific Interactions: Competition and Predation

Study the dynamics of competition and predation between different species in a community.

Simulation GameCase Study Analysis
Interspecific Interactions: Symbiosis

Investigate symbiotic relationships: mutualism, commensalism, and parasitism.

Gallery WalkJigsaw
Ecological Succession

Examine the processes of primary and secondary succession and their role in ecosystem recovery.

Experiential LearningConcept Mapping
Biodiversity and Ecosystem Services

Study the importance of biological diversity and the ecosystem services it provides.

Project-Based LearningSocratic Seminar
Keystone Species and Trophic Cascades

Investigate the impact of keystone species on ecosystem structure and the concept of trophic cascades.

Case Study AnalysisInquiry Circle