United States · Common Core State Standards
12th Grade Biology
An intensive exploration of the mechanisms of life from molecular interactions to ecosystem dynamics. Students analyze complex biological systems using evidence based inquiry to understand how life sustains itself and evolves in a changing world.

01The Molecular Basis of Life
Investigation into the chemical foundations of biological systems and the specialized functions of cellular organelles.
Examine the unique properties of water and its critical role in biological processes and cellular function.
Explore the versatility of carbon as the backbone of organic molecules and its role in forming diverse biological compounds.
Analyze the structures and diverse functions of carbohydrates and lipids in energy storage, structural support, and signaling.
Investigate the complex structures of proteins and their myriad roles as enzymes, transporters, and structural components.
Examine the structure and function of DNA and RNA as the carriers of genetic information and their roles in gene expression.
Study the role of enzymes as biological catalysts and their regulation within metabolic pathways.
Investigate the specialized structures and functions of eukaryotic and prokaryotic cell organelles.
Examine the light-dependent and light-independent reactions of photosynthesis and their importance for life on Earth.
Study the stages of cellular respiration (glycolysis, Krebs cycle, electron transport chain) and ATP production.
Investigate the fluid mosaic model of the cell membrane and its role in regulating substance passage.
Compare and contrast passive transport (diffusion, osmosis, facilitated diffusion) and active transport mechanisms.
Study how cells receive, process, and respond to external signals through signal transduction pathways.
Examine the stages of the cell cycle and the process of mitosis for growth and repair.

02Information Storage and Transfer
Focus on the mechanisms of heredity, gene expression, and the ethical implications of genetic engineering.
Investigate the semi-conservative nature of DNA replication and the enzymes involved.
Explore the process of transcription, where genetic information from DNA is copied into RNA.
Study the process of translation, where mRNA is used to synthesize proteins at the ribosome.
Investigate mechanisms of gene regulation in prokaryotes and eukaryotes, including epigenetic modifications.
Examine the process of meiosis and how it generates genetic diversity in sexually reproducing organisms.
Apply Mendel's laws of inheritance to predict patterns of trait transmission.
Investigate complex inheritance patterns such as incomplete dominance, codominance, and polygenic traits.
Use pedigree charts to track genetic traits and disorders through human generations.
Explore the tools and techniques used to manipulate DNA, including recombinant DNA technology and PCR.
Investigate the CRISPR-Cas9 system and its applications in gene editing, along with associated ethical considerations.
Study the fields of genomics and proteomics, focusing on large-scale analysis of genes and proteins.
Examine the applications of DNA profiling in forensic science, paternity testing, and conservation.
Discuss the societal and ethical implications of genetic technologies, including privacy and access.

03Evolutionary Dynamics
Analyzing the evidence for evolution and the mechanisms that drive the diversification of life on Earth.
Explore the historical context of Darwin's theory and the core principles of natural selection.
Investigate mutation and gene flow as sources of genetic variation and evolutionary change.
Study genetic drift (bottleneck and founder effects) and non-random mating as evolutionary forces.
Examine how organisms adapt to their environments and the concept of evolutionary fitness.
Investigate the mechanisms of speciation, including allopatric and sympatric speciation.
Analyze fossil records and radiometric dating to understand Earth's history and evolutionary changes.
Examine homologous and analogous structures and developmental similarities as evidence for common ancestry.
Study molecular clocks, DNA, and protein sequence comparisons to infer evolutionary relationships.
Interpret and construct phylogenetic trees and cladograms to represent evolutionary relationships.
Apply the Hardy-Weinberg principle to calculate allele and genotype frequencies in populations.
Investigate how natural selection, genetic drift, gene flow, mutation, and non-random mating disrupt Hardy-Weinberg equilibrium.
Examine different patterns of evolution, including convergent evolution, divergent evolution, and coevolution.
Study the causes and consequences of mass extinctions and subsequent adaptive radiations.

04Ecological Interactions
Exploring the complex relationships between organisms and their environments across different scales.
Identify biotic and abiotic components of ecosystems and trace energy flow through trophic levels.
Investigate the cycling of carbon and nitrogen through living organisms and the environment.
Study the water and phosphorus cycles and their importance for ecosystem health.
Model population growth using exponential and logistic growth curves and analyze limiting factors.
Differentiate between density-dependent and density-independent limiting factors affecting population size.
Examine human population growth patterns, demographic transitions, and their environmental impacts.
Study the dynamics of competition and predation between different species in a community.
Investigate symbiotic relationships: mutualism, commensalism, and parasitism.
Examine the processes of primary and secondary succession and their role in ecosystem recovery.
Study the importance of biological diversity and the ecosystem services it provides.
Investigate the impact of keystone species on ecosystem structure and the concept of trophic cascades.