Chromosomes and Genes
Students will understand that chromosomes carry genes and explore the basic relationship between them.
About This Topic
Students will understand that chromosomes carry genes and explore the basic relationship between them.
Key Questions
- Critically evaluate how chromatin remodelling and histone modification function as epigenetic mechanisms that regulate gene expression without altering DNA sequence, using specific examples from developmental biology or oncogenesis.
- Analyse the molecular requirements for chromosome stability, including telomere maintenance, centromere specification, and replication origin fidelity, and evaluate the consequences of their failure for genomic integrity.
- Synthesise the relationship between three-dimensional chromosome organisation and gene regulation, evaluating how topologically associating domains and enhancer-promoter looping govern tissue-specific transcription.
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