Translation: Ribosome Function, Codon Recognition, and Polypeptide Elongation
Students will understand the relationship between genes, chromosomes, and the expression of traits in organisms.
Key Questions
- Explain the molecular events of translation initiation, elongation — including aminoacyl-tRNA selection, peptide bond formation catalysed by peptidyl transferase rRNA, and translocation — and termination, specifying the roles of the A, P, and E sites of the ribosome at each step.
- Analyse how the degeneracy and universality of the genetic code confer robustness to certain point mutations and enable heterologous expression of human proteins in bacterial systems, evaluating the limitations imposed by codon bias.
- Evaluate the mechanisms of action of antibiotics that selectively target bacterial ribosomes — including streptomycin, erythromycin, and chloramphenicol — explaining the structural basis for their selectivity and the molecular mechanisms by which bacteria evolve resistance.
MOE Syllabus Outcomes
Suggested Methodologies
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