The Cell Cycle: Phases, Checkpoint Regulation, and CDK-Cyclin Complexes
Students will explore anaerobic respiration and fermentation, understanding how cells generate energy in the absence of oxygen and its applications.
About This Topic
Students will explore anaerobic respiration and fermentation, understanding how cells generate energy in the absence of oxygen and its applications.
Key Questions
- Explain the roles of cyclin-dependent kinases and their cyclin partners in driving progression through the G1/S and G2/M checkpoints, and analyse how loss of checkpoint control results in unrestricted cell proliferation.
- Compare the molecular events occurring in G1, S, G2, and M phases of the cell cycle, justifying why completion of S phase is a prerequisite for entry into mitosis and why re-replication of DNA must be prevented.
- Evaluate the evidence from cell cycle mutant studies in yeast that identified the molecular components of cell cycle checkpoints, and explain how these findings translated into our understanding of cancer cell biology.
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